Platelets are small fragments, but they are of crucial importance for the coagulation. The risk of spontaneous bleeding increases when the level of platelets falls below a thrombocyte particle concentration threshold value of 50 x 109/L. In those cases a platelet transfusion might be compulsory. Ongoing research tries to improve the quality of the platelets and to increase the safety of the method used. However, we still need to better understand which factors that affect how patients react upon platelet transfusion.

 Conclusion:Medical treatment may have a role in platelet count after transfusion. Since the TACSI platelets passed the quality requirements, and the vast majority of patients platelet count increased after TACSI platelet transfusion, the TACSI platelets will replace the old method to produce platelets at the Uppsala University hospital.  Methods: A new approach that pools 8 buffy coats (TACSI platelets) that were separated into 2 units instead of 4-6 buffy coats pooled to 1 unit was investigated in this study. After the platelets were extracted from the buffy coats their quality was controlled and subsequently the platelet product was evaluated in 96 patients. Results: The results showed that 80 % of the platelet units passed the European quality requirements. Further, the platelet count was increased in most patients that received TACSI platelets. Conclusion: Medical treatment may have a role in platelet count after transfusion.

Incompatibility between donors and recipients can cause fatal hemolytic transfusion reactions (HTR), kidney damage and death and immunization of the recipient. Antigens on the surface of erythrocytes in the ABO blood group system and regular natural antibodies against these in the patient?s plasma must be considered. An individual always has a corresponding antibody of IgM in their plasma. Irregular antibodies acquired by transfusion or pregnancy and active in body temperature also cause the HTR incompatibility.

Bakgrund: Blodtransfusion behövs inom vården och har en livsförbättrande effekt. Det krävs att personalen har ett korrekt handhavande om symtom på komplikationer vid transfusion uppkommer. Sjuksköterskor behöver hålla sig uppdaterade på ny forskning för att kvalitetsäkra vården. Personen som ska donera blod måste vara frisk och ha en livsföring som minimerar risken för blodsmitta. Donationen ska ske frivilligt.

Sammanfattning Bakgrund:Sedan början på förra århundrandet är blodtransfusioner en av de främsta livräddande medicinska behandlingarna. Sjuksköterskan är ansvarig under hela arbetsprocessen vid administrering av blodprodukter. Sjuksköterskans arbete utgör en livsviktig uppgift som innefattar patientsäkerhet genom att sjuksköterskan övervakar patienten för att tidigt kunna upptäcka symtom och därmed förhindra att allvarliga och livshotande komplikationer uppstår.Syfte:Syftet var att belysa blodtransfusioner utifrån sjuksköterskans och patientens erfarenheter.Metod:Metoden som användes var en litteraturbaserad studie enligt Friberg. Datainsamlingen utfördes i databaserna Cinahl with full text och Pubmed with full text med sökorden nursing, nursing care, blood transfusion, transfusion, patient care och patient experience. Resultatet baserades på sex vetenskapliga publikationer med både kvalitativ och kvantitativ design.

Platelet transfusions can be necessary during treatment of patients with thrombocytopenia or impaired platelet function. Platelet function in platelet concentrates (PC) deteriorate with storage time. Studying swirling is often used to control the quality of PC?s before transfusion but the method has some disadvantages. Therefore other methods can be useful, for example impedance aggregometry (IA, Multiplate® Analyzer) to measure platelet function.     In this study the change in platelet function over time was examined in buffy coat and apheresis platelets with IA where aggregation had been induced with adenosine diphosphate (ADP) and collagen.

Following the wake of the AIDS-catastrophe in the beginning of the eighties, homosexual men or 'men who have sex with men' (MSM) have been barred from donating blood throughout the planet. In this thesis I look into the different discourses at play in the context of creating the legal framework for blood donation in Sweden. Genealogically tracing the emergence of the category of MSM and mapping how the category is brought to use in contemporary negotiations on blood safety, I scrutinize how scientific truth is established within blood transfusion practice. I argue that the rationality of risk group exclusion is contingent on economical grounds, and that the foucauldian concept of biopolitics could productively be used to understand this rationality. In particular, the concept of the 'biopolitics of blood' can be employed in order to understand the reluctance from the involved actors to acknowledge the heteronormative consequences of the legal framework of contemporary blood donation..

Katternas AB-blodgruppssystem består av blodgrupperna A, B och AB. Blodgrupperna nedärvs dominant och A-allelen är helt dominant över B-allelen. AB är troligen en tredje allel som är dominant över B och recessiv till A. Blodgrupp A definieras av att N-glykolylneuraminsyra uttrycks på erytrocyterna och blodgrupp B av att N-acetylneuraminsyra uttrycks. Blodgrupp AB definieras av att båda neuraminsyrorna uttrycks tillsammans på erytrocyterna.

Vid mätning av HbA1c i blod visas medelkoncentrationen av glukos som en person har haft under de senaste tre månaderna och analysen används vid uppföljning av patienter med diabetes mellitus. DCA VantageTM är ett patientnära analysinstrument som utvecklats för att kunna utföra laboratorieanalyser inom till exempel primärvården. Patientnära analysinstrument är viktiga för att minska tiden från provtagning till behandling. DCA VantageTM är ett halvautomatiskt analyssystem som utformats för kvantitativa mätningar av HbA1c i blod. Syftet med studien var att utföra en verifiering för att se om DCA VantageTM (immunoturbimetrisk metod) kunde användas som ett komplementinstrument till VariantTM II Turbo (high performance liquid chromatography, HPLC).

Bakgrund: Sambandet mellan hjärtkirurgi med extracorporeal cirkulation (ECC) och blodtransfusion visar risker så som ökad morbiditet och mortalitet. Detta kan orsaka lidande för patienten och leda till kostnader för samhället. Att hantera och administrera blodprodukter är en omvårdnadshandling som sjuksköterskan ansvarar för och detta ställer därför krav på dennes kompetens. Syftet: Syftet med denna studie var att studera intensivvårdssjuksköterskors kunskap om att ge blodtransfusion till patienter som genomgått hjärtkirurgi med ECC och om de ansåg sig ha kunskap om hur blodprodukter ska handhas och administreras på ett patientsäkert sätt, samt vilket behov av kompetensutveckling de ansåg sig ha. Metod: Studien som utfördes hade en kvantitativ design med deskriptiv ansats. Ett icke-slumpmässigt urval gjordes på en Thoraxintensivvårdsavdelningen vid ett universitetssjukhus i Mellansverige och 30 intensivvårdssjuksköterskor inkluderades. Resultat: Intensivvårdsjuksköterskorna hade en mycket låg till låg kunskap om de postoperativa komplikationer vid hjärtkirurgi med ECC som kan ha ett samband med blodtransfusion. Inget statistiskt signifikant samband kunde fastställas mellan intensivvårdsjuksköterskornas upplevda kunskap och faktiska kunskap om dessa postoperativa komplikationer.

Samfundet Jehovas vittnen avsäger sig blodtransfusion på grund av sin religiösa tro. Sjukvården ställs inför etiska problem när det uppstår en situation då patienten behöver blodprodukter. För vårdaren uppstår etiska konflikter mellan viljan att rädda liv, medicinska och juridiska aspekter samt patientens autonomi. Syftet med vår uppsats är att belysa de etiska problem som vårdaren kan möta i sjukvårdspraxis. Metoden som använts är en kvalitativ litteraturstudie och bygger på fyra vetenskapliga artiklar och en avhandling.

Immune-mediated haemolytic anaemia (IMHA) is an immune-mediated destruction of erythrocytes and is one of the most common haematological diseases diagnosed in dogs. The haemolysis is a type II immunoreaction and is initiated by IgG or IgM antibodies or complements. This retrospective study includes 63 dogs suffering from primary IMHA. The study was based on information from records from the Swedish University of Agricultural Sciences, Department of Small Animal Clinical Sciences in Uppsala and from the Animal Hospital in Strömsholm. The aim of the study was to evaluate the progress of the disease, treatment and the prognostic factors in different breeds, gender and age. Following criteria were used for the dogs to be allowed in the study: the dogs were diagnosed with anaemia, the anaemia was regenerative and autoagglutination and/or spherocytes were seen in the blood. About 50 % of the dogs in the study were diagnosed with IMHA within 2-6 years of age. Wire-haired dachshund was remarkably one of the most common breeds in this study together with Cocker and Springer spaniel.

The well-being of employees has become a key concept in the rhetoric of the company boards and business literature of today. There is however not much statistic evidence of a connection between economic results and the perceived working climate. This thesis sets out to investigate whether there is a positive correlation between economic results and working climate on a work group level. It also aims to study which specific working climate factors influence the results. In order to meet its purpose this thesis analyzes employee satisfaction questionnaire data and economic results from more than 300 work groups.

Introduction: The Reading the Mind in the Eyes Test is a widely used test for measuring aspects of social cognition. The aim of the present study was to provide results from a group of typically developing Swedish children (age 9-12) and to compare these results with children and adults in other Swedish and English studies, as well as results from a group of children with Asperger syndrome. Method: A Swedish version of the child version of the test was completed by 83 controls and by six children with Asperger syndrome. Results were compared between the two groups and with data from other studies. Results: The children in the current study did not differ on scores compared to children in the same age group in other studies.

The purpose of this thesis is to examine whether institutional ownership has an influence on CEO compensation in companies where the institutions have invested. In order to fulfil the purpose of the thesis a quantitative study was carried out within the Swedish corporate context where we have studied Swedish institutional investors and companies quoted on the Stockholm Stock Exchange. Our period of study was the financial year of 2007.The empirical questions at issue is; Was there a connection between Swedish institutional ownership and the size of the CEO compensation, and, does Swedish institutional ownership lead to a certain type of CEO compensation in terms of structure?Our results did not suggest that an increased institutional ownership neither leads to a certain type of salary level nor a certain kind of salary structure. These results contradict earlier American research, which has been done within this area and has previously shown a secured connection.The reasons for our results may be many and it is difficult to state any concrete conclusions to why we received differing results.